Variable time point (minutes) | |||

T0 | T15 | T30 | |

IOP (mmHg) | 18.9 (4.3) | 19.5 (3.2) | 18.6 (4) |

PS (mm) | 8 (7–10) | 3 (3–4.8) (P<0.0001) | 2.5 (2–3.8) (P<0.0001) |

SAP (mmHg) | 148.7 (39.5) | 147.9 (28.0) | 138.0 (19.0) |

MAP (mmHg) | 108.4 (24.0) | 111.6 (21.8) | 106.5 (13.8) |

DAP (mmHg) | 94.1 (36.8) | 89.4 (20.6) | 85.4 (14.3) |

HR (beats per minute) | 116 (31) | 58 (31) (P^{b}=0.001) | 41 (10) (P^{b}<0.0001) |

f_{R} (breaths per minute) | 38 (11) | 21 (7) (P^{b}<0.0001) | 18 (7) (P^{b}<0.0001) |

T (°C) | 38.8 (0.6) | 38.9 (0.6) | 38.6 (0.5) |

Data are given as mean (sd) if the distribution was normal or as median (first quartile–third quartile) if the distribution was not normal.

P values refer to significant differences with respect to those obtained at T0. For multiple comparisons in the case of PS, P<0.017 is considered significant. In the rest of the multiple comparisons, P

^{b}denotes P value adjusted by Bonferroni correction, where P^{b}<0.05 is considered significant.DAP, diastolic non-invasive blood pressure; f

_{R}, respiratory rate; HR, heart rate; IOP, intraocular pressure; MAP, mean non-invasive blood pressure; PS, pupil size; SAP, systolic non-invasive blood pressure; T, temperature.