Table 2

IOP, PS and other variables measured at one (Tt1), five (Tt5) and ten (Tt10) minutes after intravenous administration of fentanyl (fentanyl group) or saline (control group)

VariableGroupTime point (minutes)
Tt1Tt5Tt10
IOP (mmHg)Control19.0 (3.3)18.1 (2.6)17.5 (3.6)
Fentanyl21.7 (4.0)
(Pb=0.048)
21.9 (3.2)
(Pb=0.001)
22.9 (3.2)
(Pb<0.0001)
PS (mm)Control2.5 (2–4)3 (2–3.8)3 (2–4.8)
Fentanyl2.5 (1.6–3)3 (1.3–3)2.5 (1.3–3)
SAP (mmHg)Control139.4 (19.5)130.4 (27.3)125.4 (17.1)
Fentanyl133.3 (17.2)131.9 (20.3)130 (18.3)
MAP (mmHg)Control106.8 (13.6)94.6 (22.6)94.0 (15.3)
Fentanyl101.6 (16.9)101 (16.2)97.3 (14.3)
DAP (mmHg)Control86.8 (12.8)74.3 (20.4)74.3 (14.8)
Fentanyl81.4 (17)81.3 (13.7)77.5 (13.3)
HR (beats per minute)Control64 (23)60 (20)54 (32)
Fentanyl50 (12)41 (13)50 (21)
fR (breaths per minute)Control18 (9)17 (6)19 (6)
Fentanyl16 (7)29 (41)52 (59)
T (°C)Control38.7 (0.4)38.3 (0.7)38.2 (0.8)
Fentanyl38.5 (0.7)38.2 (0.8)38.3 (0.8)
  • Data are given as mean (sd) if the distribution was normal or as median (first quartile–third quartile) if the distribution was not normal.

  • Comparisons were performed between groups at Tt1, Tt5 and Tt10. Pb denotes P value adjusted by Bonferroni correction, where Pb<0.05 is considered significant.

  • DAP, diastolic non-invasive blood pressure; fR, respiratory rate; HR, heart rate; IOP, intraocular pressure; MAP, mean non-invasive blood pressure; PS, pupil size; SAP, systolic non-invasive blood pressure; T, temperature.