Control—treated cases, successful outcomes (D0)Control—treated cases, failed outcomes (D0)Control—treated cases, failed outcomes (WD)
MIC range (µg/ml)(MIC50)*MIC range (µg/ml)(MIC50)*MIC range (µg/ml)(MIC50)*
E coliNA (n=0)NA4–16 (n=5)84–16 (n=4)16
P mirabilisNA (n=0)NA4–8 (n=2)NA4–8 (n=2)NA
P aeruginosaNA (n=0)NA64 to >64 (n=7)>64>64 (n=7)NA
S pseudintermedius4 (n=6)NA4 (n=26)NA2–4 (n=23)4
Beta-haemolytic Streptococci speciesNA (n=0)NA2 (n=10)NA2 (n=8)NA
M pachydermatis0.008–0.06 (n=8)0.030.008–0.25 (n=47)0.030.008–0.12 (n=41)0.03
  • *If 10 or more isolates, MIC50 reflects the florfenicol (E coli, P mirabilis, P aeruginosa, S pseudintermedius,beta-haemolytic Streptococci species) or terbinafine (M pachydermatis) concentration that inhibited at least 50% of the isolates being described.

  • MIC, minimal inhibitory concentration.

  • NA is used here to denote where an MIC50 was not or could not be determined: i) for pathogens for which there were fewer than 10 isolates that completed the study (e.g Proteus mirabilis), or ii) pathogens for which fewer than 50% of evaluable cases experienced successful clinical outcomes.