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Antimicrobial prescriptions and adherence to prudent use guidelines for selected canine diseases in Switzerland in 2016
  1. Bérénice Lutz1,
  2. Claudia Lehner1,
  3. Kira Schmitt2,
  4. Barbara Willi2,
  5. Gertraud Schüpbach3,
  6. Meike Mevissen4,
  7. Ruth Peter5,
  8. Cedric Müntener5,
  9. Hanspeter Naegeli5 and
  10. Simone Schuller1
  1. 1Department Clinical Veterinary Medicine, Division Small Animal Internal Medicine, Vetsuisse Faculty University of Bern, Bern, Switzerland
  2. 2Clinic for Small Animal Internal Medicine, Vetsuisse Faculty University of Zurich, Zurich, Switzerland
  3. 3Veterinary Public Health Institute, Vetsuisse Faculty, University of Bern, Bern, Switzerland
  4. 4Division of Pharmacology and Toxicology, Vetsuisse Faculty, University of Bern, Bern, Switzerland
  5. 5Institute of Veterinary Pharmacology and Toxicology, Vetsuisse Faculty University of Zurich, Zurich, Switzerland
  1. Correspondence to Prof Hanspeter Naegeli; hanspeter.naegeli{at}vetpharm.uzh.ch

Abstract

Background Antimicrobial resistance is an increasing problem in human and veterinary medicine and is closely linked to the use of antimicrobials. The objective of this study was to describe antimicrobial prescriptions for selected canine diseases in Switzerland during 2016.

Methods Dogs presented to two university hospitals and 14 private practices for acute diarrhoea (AD; n=371), suspected or confirmed urinary tract infections (UTIs; n=245), respiratory tract infections (RTIs; n=274) or wound infections (WIs; n=175) were included. Clinical history, diagnostic work-up and antimicrobial prescription (class, dosage and duration) were retrospectively assessed. A justification score was applied to evaluate appropriateness of antimicrobial therapy based on available national and international consensus guidelines.

Results Antimicrobials were prescribed in 65 per cent of dogs with AD, 88 per cent with UTI, 62 per cent with RTI and 90 per cent with WI. The most prescribed antimicrobial classes (monotherapy and combination therapy) were potentiated aminopenicillins (59 per cent), nitroimidazoles (22 per cent), non-potentiated aminopenicillins (16 per cent) and fluoroquinolones (13 per cent). Overall, 38 per cent (95 per cent CI 0.35 to 0.41) of the prescriptions were in accordance with consensus guidelines. In dogs with AD, antimicrobial therapy was associated with the presence of haemorrhagic diarrhoea (P<0.05) and complied in 32 per cent with consensus guidelines, which recommend antimicrobial treatment only when sepsis is suspected. A bacterial aetiology was confirmed via culture and/or sediment examination in 36 per cent of dogs with suspected UTI.

Conclusions Overall, adherence to consensus guidelines was poor both, at university hospitals and private practices. Antimicrobial stewardship measures are therefore needed to improve prudent use.

  • antimicrobial stewardship
  • dogs
  • prescribing habits
  • antimicrobial resistance
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Footnotes

  • Presented at An abstract has been presented at the 2019 ECVIM Congress in Milan.

  • Funding This research was supported by Swiss National Science Foundation Foundation (NRP72 project 407240_167054).

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Data are available upon request.

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