Table 2:

Immunohistochemical results on the canine hepatocellular tumours

AntibodyHCC (n=5)HCA (n=6)
PDGFRα+++ (cytoplasmic)+ (cytoplasmic)
CD290 (n=1)
+ – ++ (cytoplasmic; n=4)
0
Laminin+++ (cytoplasmic)0 (n=2)
+ (cytoplasmic; n=4)
Bmi-10 (n=1)
++ (nuclear and slight cytoplasmic; n=4)
0 – + (nuclear)
Glypican-3+++0
NF20 (n=2)
+ (cytoplasmic; n=3)
++ (cytoplasmic and membranous)
MAC387+ - +++ - ++
CD133+ (cytoplasmic)0
  • Intensity of immunohistochemical staining on the hepatocellular tumours; 0, no staining; +, slight staining; ++, moderate staining; +++, marked staining.

  • Bmi-1, B-cell-specific Moloney murine leukaemia virus integration site 1; CD133, prominin-1; HCA, hepatocellular adenoma; HCC, hepatocellular carcinoma; NF2, neurofibromatosis type 2; MAC387, macrophage antigen 387; PDGFRα, platelet-derived growth factor receptor alpha polypeptide.